Plasma Fractionation Market

Global Plasma Fractionation Market Size (2023 to 2028)

As per our report, the global plasma fractionation market is estimated to grow at a CAGR of 7.2% during the forecast period. This market is expected to be worth USD 36.25 billion by 2028 and USD 25.6 billion in 2023.

Plasma is the liquid portion of blood. It consists of red cells, white cells, and platelets suspended. It contains thousands of distinct proteins and other substances like electrolytes, minerals, hormones, and others, necessary for the human body's normal function. For example, plasma helps in maintaining blood pressure and body temperature regulation.

MARKET DRIVERS:

Y-O-Y growth in the prevalence of respiratory diseases worldwide is another significant factor boosting the global plasma fractionation market growth.

Respiratory disorders such as asthma, COPD, and new acute coronavirus disease. According to NIH, Plasma from COVID-19-recovered donors may produce antibodies to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may help suppress the virus and alter the inflammatory response. More than 70,000 patients in the United States have received COVID-19 convalescent plasma through the Mayo Clinic's Expanded Access Program (EAP), which was created to provide widespread access to investigational convalescent plasma.

The growing aging population with related blood-related ailments is also set to drive the global plasma fraction market growth.

Globally, the population is aging at an alarming pace in emerging countries such as India, China, Japan, etc. World Health Organization (WHO) says people live longer lives worldwide. Between 2015 and 2050, the proportion of the world's population over 60 years old is expected to grow from 12% to 22%. By 2050, low- and middle-income countries will house 80% of the elderly.

Increasing usage of immunoglobulins in different areas is a significant factor driving the global plasma fractionation market.

Factors such as the increasing incidence of immune and bleeding disorders, the growing prevalence of Alpha-1 Antitrypsin deficiency, and the increasing use of immunoglobulins, which are antibodies, propel the global plasma fractionation market. In addition, the emergence of novel and innovative products to treat immunological deficiencies, inherited metabolic disorders, and trauma and the rising number of FDA approvals provide lucrative opportunities for the growth of plasma fractionation globally.

MARKET RESTRAINTS:

Increasing use of recombinant proteins and products that replace plasma products and the risk factors associated with them, escalating prices of plasma derivatives, unfavorable reimbursement policies, and increased use in prophylactic therapies are likely to restrain the global plasma fractionation market growth. In addition, regulatory authorities strictly govern plasma products since they are made from whole blood. Stringent regulations governing the manufacturing plant, the source of whole blood, and the isolation procedure, among other things, could limit the market's expansion. Such strict policies will affect the product's production and processing time and the market's growth in the coming years.

Impact of COVID-19 on the global plasma fractionation market:

The COVID-19 pandemic is expected to drive significant global plasma fractionation market growth. Some countries are working with plasma fractionation techniques to discover new cures and diagnostic methodologies for the novel coronavirus. Using convalescent plasma as a treatment for COVID-19-positive patients may be viable. Plasma is extracted from a previously infected person's blood and then given to an actual patient. As a result of the plasma containing vital antibodies to combat the infection, the patient receives passive immunization. Octapharma, a major pharmaceutical company, is using its knowledge to search for new COVID-19 drugs. It is working with leading plasma fractionation market players to improve a possible plasma-derived hyperimmune immunoglobulin treatment. The alliance is looking at developing an unbranded anti-SARS-CoV-2 polyclonal hyperimmune immunoglobulin. Patients with severe COVID-19 symptoms can benefit from the treatment. The company gathers convalescent plasma to help fund preclinical and clinical research on whether the anti-SARS-CoV-2 hyperimmune immunoglobulin helps treat COVID-19. The spread of the COVID-19 pandemic has also resulted in a reduction in the number of blood donors and plasma collections in certain countries, hampered the economy by causing a shortfall in raw material availability.

The COVID-19 pandemic has severe consequences for blood transfusion. According to the NIH COVID-19 Care Guidelines panel, there is insufficient evidence to recommend either for or against monoclonal antibodies for treating outpatients with mild to moderate COVID. To maximize revenue during the pandemic, players in the plasma fractionation market are increasing their investments in potential immunoglobulin covid-19 vaccine production applications. In 2020, several leading biopharmaceutical firms joined forces to find therapeutic alternatives to the current global pandemic. Although there is little known about plasma-derived therapies in general, the COVID-19 pandemic has shed light on this form of therapy and highlighted its wider applications in everyday medicine. The importance of this field of pharmaceutical medicine and healthcare became clear as its understanding of the novel coronavirus increased. In response to the pandemic, the major global players in plasma-derived medicinal products formed the CoVIg-19 Plasma Alliance to accelerate the production of investigational hyperimmune immunoglobulin therapy for the treatment of COVID-19. Convalescent plasma has been commonly used to treat coronavirus disease 2019 (Covid-19); it is unclear if convalescent plasma with high antibody levels, as opposed to low antibody levels, is associated with a lower risk of death.

REPORT COVERAGE:

This research report on the global plasma fractionation market has been segmented and sub-segmented based on the product, application, end-user, and region.

Plasma Fractionation Market – By Product:

• Albumin
• Immunoglobulin
• Factor VIII
• Protease Inhibitors

The immunoglobulin segment is expected to dominate the global plasma fractionation market by contributing a significant share based on the product during the forecast period. Factors such as the increasing focus of immunology research and the growing adoption of immunoglobulin in primary and secondary immune deficiencies, inflammatory diseases, and autoimmune diseases are helping this segment experience to accumulate significantly during the forecast period.

Plasma Fractionation Market – By Application:

• Neurology
• Hematology
• Rheumatology
• Pulmonology
• Immunology

Based on the application, the neurology segment dominated the plasma fractionation market accounting for the major market share in 2022, and is expected to be the rapidly growing segment during the forecast period owing to increasing demand for plasma fractionation products for the treatment and improving plasma fractionation applications products in the neurology field.

Plasma Fractionation Market – By End-user:

• Hospital
• Clinical Laboratories

Plasma Fractionation Market – By Region:

• North America
• Europe
• Asia Pacific
• Latin America
• The Middle East and Africa

As of 2021, the North American plasma fractionation market accounted for the major global market share, with the U.S. accounting for a significant share. The presence of a high number of registered hemophilic patients and the increasing use of immunoglobulins in neurologic disorders are supporting the market to growth in this region. Europe comes in second in market share due to rising awareness about blood-related diseases and the swift availability of treatment in terms of plasma fractionation.

The European plasma fractionation market is projected to showcase a healthy CAGR during the forecast period. As a result, countries such as the UK, Germany, and France are predicted to hold a major share of the European market in the coming years.

On the other hand, the Asia-Pacific plasma fractionation market is estimated to grow at the highest CAGR during the forecast period, majorly because of the presence of more significant elderly population numbers leading to a higher incidence of blood disorders. As a result, India, China, and Japan are expected to account for the leading share of the regional market in the coming years.

The Latin American plasma fractionation market is predicted to hold a considerable share of the worldwide market during the forecast period.

The plasma fractionation market in the MEA is forecasted to grow at a moderate growth rate in the coming years.

KEY MARKET PARTICIPANTS:

Some of the notable companies playing a leading role in the global plasma fractionation market profiled in this report are CSL Ltd. (Australia), Grifols S.A (Spain), Baxalta Incorporated (U.S.), Octapharma AG (Switzerland), Kedrion S.p.A (Italy), Bio Products Laboratory (U.K.), Sanquin (Netherland), China Biologic Products, Inc. (China), Biotest AG (Germany), and Laboratoire Français du Fractionnement et des Biotechnologies (France).

KEY HAPPENINGS IN THIS MARKET:

• In 2019, Shire Company was acquired by Takeda pharmaceutical company limited to expand its customer base and distribution network across the globe.
• In 2018, Octapharma inaugurated a multi-function facility. This unit provides new production lines for immunoglobulin panzyga. 
• In 2018, Grifols Company launched GamaSTAN immune globulin to treat the hepatitis A virus.
• In 2018, Biotest Corporation was acquired by Grifols to increase its plasma collection network in the U.S.
• In 2018, Guizhou Taibang biological products co. Ltd. received approval from the family planning commission and Hainan provincial health to build a new plasma collection station.